TRIM21, tripartite motif containing 21, 6737

N. diseases: 229; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.040 Biomarker disease BEFREE Our data show that RNA markers of SSA/Ps advance the distinction of serrated lesions and contribute to the study of the serrated pathway to colon cancer. 31789933 2019
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.020 Biomarker disease BEFREE Our data show that RNA markers of SSA/Ps advance the distinction of serrated lesions and contribute to the study of the serrated pathway to colon cancer. 31789933 2019
CUI: C0264545
Disease: Thickening of pleura
Thickening of pleura 		0.010 Biomarker disease BEFREE Compared with CTD-ILD patients, IPAF patients were more likely to present initially with respiratory symptoms, with higher rates of fever, cough and expectoration, dyspnea, and Velcro crackles; anti-Ro52 titers were higher; incidences of honeycombing opacity, reticulate opacity, patchy opacity, and pleural thickening were greater. 31758424 2020
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.020 Biomarker group BEFREE SSA has a high stroke incidence and post-stroke morbidity. 31731111 2020
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE Traditional serrated adenoma (TSA) remains the least understood of all the colorectal adenomas, although these lesions have been associated with a significant cancer risk, twice that of the conventional adenoma (CAD) and of the sessile serrated adenoma (SSA/P). 31729028 2020
CUI: C2732618
Disease: Sessile Serrated Adenoma/Polyp
Sessile Serrated Adenoma/Polyp 		0.100 GeneticVariation disease BEFREE Traditional serrated adenoma (TSA) remains the least understood of all the colorectal adenomas, although these lesions have been associated with a significant cancer risk, twice that of the conventional adenoma (CAD) and of the sessile serrated adenoma (SSA/P). 31729028 2020
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.080 Biomarker group BEFREE Traditional serrated adenoma (TSA) remains the least understood of all the colorectal adenomas, although these lesions have been associated with a significant cancer risk, twice that of the conventional adenoma (CAD) and of the sessile serrated adenoma (SSA/P). 31729028 2020
CUI: C1266025
Disease: Traditional Serrated Adenoma
Traditional Serrated Adenoma 		0.040 Biomarker disease BEFREE Traditional serrated adenoma (TSA) remains the least understood of all the colorectal adenomas, although these lesions have been associated with a significant cancer risk, twice that of the conventional adenoma (CAD) and of the sessile serrated adenoma (SSA/P). 31729028 2020
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine 		0.020 Biomarker disease BEFREE Traditional serrated adenoma (TSA) remains the least understood of all the colorectal adenomas, although these lesions have been associated with a significant cancer risk, twice that of the conventional adenoma (CAD) and of the sessile serrated adenoma (SSA/P). 31729028 2020
CUI: C0206062
Disease: Lung Diseases, Interstitial
Lung Diseases, Interstitial 		0.100 Biomarker group BEFREE The majority of patients with ILD and anti-Ro52 had no established connective tissue disease (78%), and one-third had no rheumatologic symptoms. 31718649 2019
CUI: C0009782
Disease: Connective Tissue Diseases
Connective Tissue Diseases 		0.070 Biomarker group BEFREE The majority of patients with ILD and anti-Ro52 had no established connective tissue disease (78%), and one-third had no rheumatologic symptoms. 31718649 2019
CUI: C0027121
Disease: Myositis
Myositis 		0.050 Biomarker disease BEFREE Our objectives were to compare presenting phenotypes of patients with anti-Ro52 alone versus in combination with myositis-specific autoantibodies and to identify predictors of disease progression or death. 31718649 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE This concept of cancer awareness training might be also applicable to other countries in SSA. 31707642 2019
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.080 Biomarker group BEFREE This concept of cancer awareness training might be also applicable to other countries in SSA. 31707642 2019
CUI: C0036916
Disease: Sexually Transmitted Diseases
Sexually Transmitted Diseases 		0.010 Biomarker group BEFREE To examine knowledge of menstruation, HIV and STIs other than HIV across eight sites in SSA to develop effective programmatic interventions enabling adolescents to achieve positive SRH as their transition to adulthood. 31691455 2020
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.100 Biomarker disease BEFREE Rowell syndrome (RS) is a rare disease characterized by the association of systemic lupus erythematosus (SLE) or cutaneous lupus with lesions similar to erythema multiforme and the presence of autoantibodies including ANA, SSA, SSB, or rheumatoid factor. 31674268 2019
CUI: C0406637
Disease: Erythema multiforme-like lupus erythematosus
Erythema multiforme-like lupus erythematosus 		0.010 Biomarker disease BEFREE Rowell syndrome (RS) is a rare disease characterized by the association of systemic lupus erythematosus (SLE) or cutaneous lupus with lesions similar to erythema multiforme and the presence of autoantibodies including ANA, SSA, SSB, or rheumatoid factor. 31674268 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 GeneticVariation group BEFREE For cancer risk, industrial sources and SSA posed the highest proportion. 31655327 2019
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.080 GeneticVariation group BEFREE For cancer risk, industrial sources and SSA posed the highest proportion. 31655327 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 GeneticVariation group BEFREE Cancer-associated mutation abolishes the impact of TRIM21 on the invasion of breast cancer cells. 31622717 2020
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 GeneticVariation group BEFREE More importantly, comparing to the xenograft tumors derived from MDA-MB-231 cells with the wild-type TRIM21, xenograft tumors derived from MDA-MB-231 cells with the R64Q mutated TRIM21 showed greatly increased infiltration into neighboring muscle fibers. 31622717 2020
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.080 GeneticVariation group BEFREE Cancer-associated mutation abolishes the impact of TRIM21 on the invasion of breast cancer cells. 31622717 2020
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.070 GeneticVariation disease BEFREE R64Q, a breast cancer-associated TRIM21 mutation, abolishes the interaction between TRIM21 and Snail, and the TRIM21-mediated ubiquitination and degradation of Snail. 31622717 2020
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.060 GeneticVariation disease BEFREE R64Q, a breast cancer-associated TRIM21 mutation, abolishes the interaction between TRIM21 and Snail, and the TRIM21-mediated ubiquitination and degradation of Snail. 31622717 2020
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.020 GeneticVariation phenotype BEFREE Collectively, our study demonstrates that the R64Q mutation abolishes the suppressive effects of TRIM21 on the invasion of breast cancer cells. 31622717 2020